Voriconazole-refractory invasive aspergillosis
نویسندگان
چکیده
منابع مشابه
Voriconazole-refractory invasive aspergillosis
Invasive aspergillosis (IA) is one of the most common life-threatening complications in immunocompromised patients. Voriconazole is currently the drug of choice for IA treatment. However, some patients with IA suffer clinical deterioration despite voriconazole therapy. Management of voriconazole-refractory IA remains challenging; no useful recommendations have yet been made. Voriconazole-refrac...
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Voriconazole is active against Aspergillus and other filamentous fungi, but it has no activity against Zygomycetes. Iowa and Boston groups reported an increase in the incidence of zygomycosis in patients given prophylactic voriconazole. Long-term use of voriconazole might exert selective pressure for growth of resistant organisms however, reviews of data from several transplantation centers sho...
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BACKGROUND Voriconazole is a broad-spectrum triazole that is active against aspergillus species. We conducted a randomized trial to compare voriconazole with amphotericin B for primary therapy of invasive aspergillosis. METHODS In this randomized, unblinded trial, patients received either intravenous voriconazole (two doses of 6 mg per kilogram of body weight on day 1, then 4 mg per kilogram ...
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DOI: 10.4274/tjh.2017.0236 Address for Correspondence/Yazışma Adresi: Rakul NAMBIAR, M.D., Regional Cancer Centre, Department of Medical Oncology, Thiruvananthapuram, India E-mail : [email protected] ORCID-ID: orcid.org/0000-0001-9670-3453 1Regional Cancer Centre, Department of Medical Oncology, Thiruvananthapuram, India 2Regional Cancer Centre, Department of Microbiology, Thiruvananthapur...
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ژورنال
عنوان ژورنال: The Korean Journal of Internal Medicine
سال: 2017
ISSN: 1226-3303,2005-6648
DOI: 10.3904/kjim.2017.109